ISID and Pfizer Independent Grants
for Learning & Change
ISID and Pfizer Independent Grants for Learning & Change (IGL&C) collaborated in 2014 to offer a grant opportunity in the area of adult vaccination. ISID and Pfizer's goal is to decrease health disparities by increasing access to or use of vaccinations by adults either individually or by population in low- and middle-income countries.

Grant Awards:
Reaching the hard-to-reach mobile pastoralists with the most appropriate vaccination scheme in Central Africa
Esther Schelling (Principal Investigator) Swiss Tropical and Public Health Institute (Swiss TPH), Basel
Mahamat Béchir Switzerland Ministry of Health and Centre de Support en Santé Internationale (CSSI), N’Djaména, Chad
Mbaihol Tamadji Chad Ministry of Health, Expanded Programme on Immunization, N’Djaména, Chad
Hamit Kessely Support en Santé Internationale (CSSI), N’Djaména, Chad
Ngandolo Bongo Naré Institut de Recherche en Élevage pour le Développement, N’Djaména, Chad


The consortium - composed of members of four public health and veterinary institutes - has the overall goal of increasing vaccination coverage among mobile pastoralists in Central Africa. In Chad with its high proportion of pastoralists, research and implementation partners have gained experience in well reaching pastoralists with joint human and animal vaccination campaigns, but a sustained strategy still needs to be better described before translation to policy. We hypothesize that the introduction of an assessed adult vaccination scheme will further increase the demand of pastoralists for vaccination services and lead to more frequent utilization of a mix between mobile, outreach and established fixed vaccination infrastructure. Given that one fifth of pastoralists regularly cross the country borders, Chad will initiate an exchange with its neighboring countries on how to serve pastoralist communities and on the appropriate vaccination scheme including adult vaccination - among the ‘lost-outs’. Main beneficiaries are the pastoralists in remote zones as well as the vaccination services. This operational research will facilitate vaccination campaigns between the health and veterinary sectors in three zones and two years. The campaigns are assessed with qualitative and quantitative approaches regarding the knowledge and perceptions on adult vaccination; randomized surveys will indicate the achieved coverage of women (TT2+) and an in-depth follow-up of few families will further show whether the overall demand to vaccination could be increased when other adult vaccines are added to the schedule. We will disseminate our results to all stakeholders to further explore how vaccinations can be sustainably delivered to these hard-to-reach communities.

Strategic Immunization Geo-temporal Mapping Application (SIGMA)

Bruce Y. Lee (Principal Investigator) International Vaccine Access Center (IVAC) and Johns Hopkins Bloomberg School of Public Health
Dagna Constenla (Co-PI) International Vaccine Access Center (IVAC) and Johns Hopkins Bloomberg School of Public Health


The overall goal is to develop the Strategic Immunization Geo-temporal Mapping Application (SIGMA), a computational modelling tool to help decision makers: (1) forecast temporal demand for current and future adult immunizations, in a given country, in different parts of the country, and for each immunization location. (2) Determine the number and characteristics of adults that are reachable by current immunization locations and strategies in any given country. (3) Plan the locations and operating characteristics of various immunization strategies (e.g., outreach, campaigns, and other strategies) that are needed to supplement the fixed immunization locations. (4) Estimate the costs and cost-effectiveness of different adult immunization strategies from estimated demand scenarios. (5) Develop guidelines for adult vaccination use, to anticipate demand and to secure appropriate funding. (6) Demonstrate how robust these answers and solutions are to varying conditions (e.g., costs, population migration, mortality, and compliance with immunization). The key objectives of this project are to develop an initial version of SIGMA and utilize SIGMA for a pilot country (Mozambique) to evaluate the immunization logistics for a currently implemented adult vaccine (tetanus) and a planned adult vaccine (HPV). To evaluate the utility of SIGMA at the end of the project period, our team will convene a focus group of potential SIGMA users to evaluate and provide feedback on.

Using novel packaging and delivery technologies to improve access to adult vaccines in low-resource settings

Zehrung, Darin L (Senior Technical Officer, Principal Investigator and project manager)

The Vaccine and Pharmaceutical Technologies Group (VPTG) at PATH, Seattle

Swaminathan, Savitha

Commercialization Associate

McGray, Sarah

Program Officer

Saxon, Eugene Alan

Product Development Engineer
Jeffers, Emily Project Administrator

James, Tessa

Program Assistant

Mayimele, Hlahla

Commercialization Officer, South Africa Office

Kumar, Sandeep

Program Officer, India Office

Odero, Christopher

Senior Program Officer, Kenya Office

Gueye, Abdoulaye

Technical Officer, Senegal Office

Dao, Sang Dinh

Program Officer, Vietnam Office

He, Yonggang

Program Officer, China Office


The scope of adult immunizations in many developing countries currently centers on a handful of vaccine-preventable diseases, but these vaccines have had limited reach within their target populations. Under this work, we will conduct an assessment of adult immunization-delivery scenarios in both low- and middle- income countries, with a focus on maternal immunizations. We will examine market requirements, program priorities, and user needs. We will identify possible constraints that may limit coverage of existing and future adult vaccines and map selected constraints to innovative packaging and delivery technologies that may help to optimize adult, particularly maternal, vaccine coverage. We will work with a variety of individual experts, but do not anticipate pursuing institutional collaborations. Instead, we will leverage the strength of PATH’s network of country offices to conduct the needs assessment.

Vaccination accessibility for child-bearing age women in low- and middle-income countries in Southeast Asia period 2015-2017

Prof. Assoc. Le Thi Huong (Project manager)

Director of the Institute for Preventive Medicine and Public Health, Hanoi Medical University, Vietnam
Dr. Vanphanom Sychareun (Project manager) Dean of the Faculty of Postgraduate Studies at the University of Health Sciences, Laos PDR


Overall, the project aims to increase the accessibility and use of vaccines to prevent some communicable diseases such as influenza, rubella, tetanus, and hepatitis B in low- and middle-income countries in Southeast Asia period 2015-2017. The project will offer opportunities for researchers in institutions and agencies involved in improving capacity in research of adult vaccination immunization.
A multi-country, prospective and community-based study will be carried out over three years (tentatively 2015-2017). Pre- and post- evaluation design and community-based randomized control trials (RCT) will be applied in two Southeast Asian countries (Vietnam, Lao PDR).
Specifically, the outcome of the project aims to decrease health disparities by evidence-based novel interventions for accessing vaccination against influenza in Vietnam and Lao PDR. Vietnam and Lao PDR will implement health education interventions; at the same time Vietnam will implement a health service intervention in order to address barriers to vaccination access in each of their respective countries and localities. In addition, at least, two papers will be submitted to international peer-reviewed journals at the end of the project.